Effect of genetic variants of the ABCC2 transporter on bioavailability of mycophenolic acid in renal-transplant patients
Mycophenolic acid (MPA) displays variable pharmacokinetics (PK). It is metabolized by UGTs to MPA-glucuronide which is subject to enterohepatic recirculation. Biliary and kidney excretion involves multidrug resistant protein 2 (MRP2) coded by ABCC2. We assessed steady-state PK of MPA in renal allograft recipients in respect to donor and recipient ABCC2 genotypes, along with other clinical covariat…
Сътрудници
- Božina, Nada
Създател
- Lalić, Zdenka
Издател
- University of Zagreb. Faculty of Pharmacy and Biochemistry.
Тема
- BIOMEDICINE AND HEALTHCARE. Pharmacy. Pharmacy.
- Biotechnology. Genetic engineering. Products of cloning
- mycophenolic acid
- pharmacokinetics
- pharmacogenetics
- MRP2/ABCC2
- renal transplant patients
- cyclosporine
- tacrolimus
Вид на обекта
- info:eu-repo/semantics/doctoralThesis
- text
Дата
- 2015-12-03
- 2015-12-03
Сътрудници
- Božina, Nada
Създател
- Lalić, Zdenka
Издател
- University of Zagreb. Faculty of Pharmacy and Biochemistry.
Тема
- BIOMEDICINE AND HEALTHCARE. Pharmacy. Pharmacy.
- Biotechnology. Genetic engineering. Products of cloning
- mycophenolic acid
- pharmacokinetics
- pharmacogenetics
- MRP2/ABCC2
- renal transplant patients
- cyclosporine
- tacrolimus
Вид на обекта
- info:eu-repo/semantics/doctoralThesis
- text
Дата
- 2015-12-03
- 2015-12-03
доставчик на данни
Права за ползване на медиите в този обект (освен ако не е посочено друго)
- http://rightsstatements.org/vocab/InC/1.0/
Идентификатор
- https://dr.nsk.hr/islandora/object/pharma:263
- https://urn.nsk.hr/urn:nbn:hr:163:726121
- https://repozitorij.unizg.hr/islandora/object/pharma:263
- https://dr.nsk.hr/islandora/object/pharma%3A263/datastream/TN/view/
Формат
- application/pdf
Език
- hrv
Предоставяне на държава
- Croatia
Име на колекцията
Публикуван за първи път в Europeana
- 2019-04-05T13:44:11.531Z
Последно актуализиран от предоставящата институция
- 2019-04-05T13:44:11.531Z