Antinociceptivno djelovanje botulinum toksina tipa A

OBJECTIVE. The hypothesis of this dissertation is that botulinum toxin type A (BT-A) has antinociceptive effect, which might include interference with mechanisms of central sensitization.
MATERIALS AND METHODS. Male Wistar rats were injected with BT-A subcutaneously, intrathecally and intraneuronally. Antinociceptive effect of BT-A was investigated in nociceptive, inflammatory and neuropathic pai…