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Effect of genetic variants of the ABCC2 transporter on bioavailability of mycophenolic acid in renal-transplant patients
Mycophenolic acid (MPA) displays variable pharmacokinetics (PK). It is metabolized by UGTs to MPA-glucuronide which is subject to enterohepatic recirculation. Biliary and kidney excretion involves multidrug resistant protein 2 (MRP2) coded by ABCC2. We assessed steady-state PK of MPA in renal allograft recipients in respect to donor and recipient ABCC2 genotypes, along with other clinical covariat…
Contributors
- Božina, Nada
Creator
- Lalić, Zdenka
Publisher
- University of Zagreb. Faculty of Pharmacy and Biochemistry.
Subject
- BIOMEDICINE AND HEALTHCARE. Pharmacy. Pharmacy.
- Biotechnology. Genetic engineering. Products of cloning
- mycophenolic acid
- pharmacokinetics
- pharmacogenetics
- MRP2/ABCC2
- renal transplant patients
- cyclosporine
- tacrolimus
Type of item
- info:eu-repo/semantics/doctoralThesis
- text
Date
- 2015-12-03
- 2015-12-03
Contributors
- Božina, Nada
Creator
- Lalić, Zdenka
Publisher
- University of Zagreb. Faculty of Pharmacy and Biochemistry.
Subject
- BIOMEDICINE AND HEALTHCARE. Pharmacy. Pharmacy.
- Biotechnology. Genetic engineering. Products of cloning
- mycophenolic acid
- pharmacokinetics
- pharmacogenetics
- MRP2/ABCC2
- renal transplant patients
- cyclosporine
- tacrolimus
Type of item
- info:eu-repo/semantics/doctoralThesis
- text
Date
- 2015-12-03
- 2015-12-03
Providing institution
Aggregator
Rights statement for the media in this item (unless otherwise specified)
- http://rightsstatements.org/vocab/InC/1.0/
Identifier
- https://dr.nsk.hr/islandora/object/pharma:263
- https://urn.nsk.hr/urn:nbn:hr:163:726121
- https://repozitorij.unizg.hr/islandora/object/pharma:263
- https://dr.nsk.hr/islandora/object/pharma%3A263/datastream/TN/view/
Format
- application/pdf
Language
- hrv
Providing country
- Croatia
Collection name
First time published on Europeana
- 2019-04-05T13:44:11.531Z
Last time updated from providing institution
- 2019-04-05T13:44:11.531Z