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Formulation and evaluation of cyclodextrin-based drug delivery system for oral application of zaleplon
Insomnia is one of the most common sleep disorders affecting about 30% of adult population, while its
prevalence is even higher among elderly and psychiatric patients. Pharmacological properties makes zaleplon the drug
of choice for the short term treatment of insomnia, but its low aqueous solubility and intensive metabolism in liver are
reducing its oral bioavailability to only 30%. Therefore, th…
Contributors
- Jug, Mario
- Kujundžić, Nikola
Creator
- Jablan, Jasna
Publisher
- University of Zagreb. Faculty of Pharmacy and Biochemistry. Department of pharmaceutical technology.
Subject
- zaleplon
- cyclodextrins
- inclusion complexes
- solubility
- spray-drying
- Eudragit
- microspheres
- pHdependent drug release
- BIOMEDICINE AND HEALTHCARE. Pharmacy. Pharmacy.
- Pharmacology. Therapeutics. Toxicology
Type of item
- info:eu-repo/semantics/doctoralThesis
- text
Date
- 2014-07-04
- 2014-07-04
Contributors
- Jug, Mario
- Kujundžić, Nikola
Creator
- Jablan, Jasna
Publisher
- University of Zagreb. Faculty of Pharmacy and Biochemistry. Department of pharmaceutical technology.
Subject
- zaleplon
- cyclodextrins
- inclusion complexes
- solubility
- spray-drying
- Eudragit
- microspheres
- pHdependent drug release
- BIOMEDICINE AND HEALTHCARE. Pharmacy. Pharmacy.
- Pharmacology. Therapeutics. Toxicology
Type of item
- info:eu-repo/semantics/doctoralThesis
- text
Date
- 2014-07-04
- 2014-07-04
Providing institution
Aggregator
Rights statement for the media in this item (unless otherwise specified)
- http://rightsstatements.org/vocab/InC/1.0/
Identifier
- https://dr.nsk.hr/islandora/object/pharma:326
- https://urn.nsk.hr/urn:nbn:hr:163:755257
- https://repozitorij.unizg.hr/islandora/object/pharma:326
- https://dr.nsk.hr/islandora/object/pharma%3A326/datastream/TN/view/
Format
- application/pdf
Language
- hrv
Providing country
- Croatia
Collection name
First time published on Europeana
- 2019-04-05T13:44:29.638Z
Last time updated from providing institution
- 2019-04-05T13:44:29.638Z