Formulation and evaluation of cyclodextrin-based drug delivery system for oral application of zaleplon
Insomnia is one of the most common sleep disorders affecting about 30% of adult population, while its
prevalence is even higher among elderly and psychiatric patients. Pharmacological properties makes zaleplon the drug
of choice for the short term treatment of insomnia, but its low aqueous solubility and intensive metabolism in liver are
reducing its oral bioavailability to only 30%. Therefore, th…
Laguntzaileak
- Jug, Mario
- Kujundžić, Nikola
Sortzailea
- Jablan, Jasna
Argitaletxea
- University of Zagreb. Faculty of Pharmacy and Biochemistry. Department of pharmaceutical technology.
Gaia
- zaleplon
- cyclodextrins
- inclusion complexes
- solubility
- spray-drying
- Eudragit
- microspheres
- pHdependent drug release
- BIOMEDICINE AND HEALTHCARE. Pharmacy. Pharmacy.
- Pharmacology. Therapeutics. Toxicology
Elementu mota
- info:eu-repo/semantics/doctoralThesis
- text
Data
- 2014-07-04
- 2014-07-04
Laguntzaileak
- Jug, Mario
- Kujundžić, Nikola
Sortzailea
- Jablan, Jasna
Argitaletxea
- University of Zagreb. Faculty of Pharmacy and Biochemistry. Department of pharmaceutical technology.
Gaia
- zaleplon
- cyclodextrins
- inclusion complexes
- solubility
- spray-drying
- Eudragit
- microspheres
- pHdependent drug release
- BIOMEDICINE AND HEALTHCARE. Pharmacy. Pharmacy.
- Pharmacology. Therapeutics. Toxicology
Elementu mota
- info:eu-repo/semantics/doctoralThesis
- text
Data
- 2014-07-04
- 2014-07-04
Erakunde hornitzailea
Agregatzailea
Elementu honen baimenen egoera (besterik adierazi ezean)
- http://rightsstatements.org/vocab/InC/1.0/
Identifikatzailea
- https://dr.nsk.hr/islandora/object/pharma:326
- https://urn.nsk.hr/urn:nbn:hr:163:755257
- https://repozitorij.unizg.hr/islandora/object/pharma:326
- https://dr.nsk.hr/islandora/object/pharma%3A326/datastream/TN/view/
Formatua
- application/pdf
Hizkuntza
- hrv
Herrialde hornitzailea
- Croatia
Bildumaren izena
Lehenengo aldiz argitaratua Europeana-n
- 2019-04-05T13:44:29.638Z
Erakunde hornitzaileak azken aldiz eguneratu du
- 2019-04-05T13:44:29.638Z