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Effect of genetic variants of the ABCC2 transporter on bioavailability of mycophenolic acid in renal-transplant patients

Mycophenolic acid (MPA) displays variable pharmacokinetics (PK). It is metabolized by UGTs to MPA-glucuronide which is subject to enterohepatic recirculation. Biliary and kidney excretion involves multidrug resistant protein 2 (MRP2) coded by ABCC2. We assessed steady-state PK of MPA in renal allograft recipients in respect to donor and recipient ABCC2 genotypes, along with other clinical covariat…

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Contribuitori

  • Božina, Nada

Creator

  • Lalić, Zdenka

Editor

  • University of Zagreb. Faculty of Pharmacy and Biochemistry.

Subiect

  • BIOMEDICINE AND HEALTHCARE. Pharmacy. Pharmacy.
  • Biotechnology. Genetic engineering. Products of cloning
  • mycophenolic acid
  • pharmacokinetics
  • pharmacogenetics
  • MRP2/ABCC2
  • renal transplant patients
  • cyclosporine
  • tacrolimus

Tipul resursă culturală

  • info:eu-repo/semantics/doctoralThesis
  • text

Dată

  • 2015-12-03
  • 2015-12-03