Effects of salt forms on the oral absorption of highly permeable weak base doxazosin

In this study, the usefulness of biorelevant in vitro data and of canine data in forecasting early exposure after the
administration of two phases of a BCS Class II compound, i.e., doxazosin base (DB) and its mesylate salt (DM)
was evaluated. DB, DM, and doxazosin hydrochloride (DH) were prepared and extensively characterized.
The solubility of prepared substances was tested in vitro in various me…