Effect of genetic variants of the ABCC2 transporter on bioavailability of mycophenolic acid in renal-transplant patients
Mycophenolic acid (MPA) displays variable pharmacokinetics (PK). It is metabolized by UGTs to MPA-glucuronide which is subject to enterohepatic recirculation. Biliary and kidney excretion involves multidrug resistant protein 2 (MRP2) coded by ABCC2. We assessed steady-state PK of MPA in renal allograft recipients in respect to donor and recipient ABCC2 genotypes, along with other clinical covariat…
Prispievatelia
- Božina, Nada
Tvorca
- Lalić, Zdenka
Vydavateľ
- University of Zagreb. Faculty of Pharmacy and Biochemistry.
Predmet
- BIOMEDICINE AND HEALTHCARE. Pharmacy. Pharmacy.
- Biotechnology. Genetic engineering. Products of cloning
- mycophenolic acid
- pharmacokinetics
- pharmacogenetics
- MRP2/ABCC2
- renal transplant patients
- cyclosporine
- tacrolimus
Typ objekt
- info:eu-repo/semantics/doctoralThesis
- text
Dátum
- 2015-12-03
- 2015-12-03
Prispievatelia
- Božina, Nada
Tvorca
- Lalić, Zdenka
Vydavateľ
- University of Zagreb. Faculty of Pharmacy and Biochemistry.
Predmet
- BIOMEDICINE AND HEALTHCARE. Pharmacy. Pharmacy.
- Biotechnology. Genetic engineering. Products of cloning
- mycophenolic acid
- pharmacokinetics
- pharmacogenetics
- MRP2/ABCC2
- renal transplant patients
- cyclosporine
- tacrolimus
Typ objekt
- info:eu-repo/semantics/doctoralThesis
- text
Dátum
- 2015-12-03
- 2015-12-03
Poskytujúca inštitúcia
Právny stav na médiá v tomto objekt (pokiaľ nie je uvedené inak)
- http://rightsstatements.org/vocab/InC/1.0/
Identifikátor
- https://dr.nsk.hr/islandora/object/pharma:263
- https://urn.nsk.hr/urn:nbn:hr:163:726121
- https://repozitorij.unizg.hr/islandora/object/pharma:263
- https://dr.nsk.hr/islandora/object/pharma%3A263/datastream/TN/view/
Formát
- application/pdf
Jazyk
- hrv
Poskytujúca krajina
- Croatia
Názov zbierky
Prvýkrát zverejnené na Europeana
- 2019-04-05T13:44:11.531Z
Naposledy aktualizované zo strany správcovskej inštitúcie
- 2019-04-05T13:44:11.531Z