Synthesis and activity of antiinflammatory conjugates of macrolide and nonsteroidal antiinflammatory drug

Nonsteroidal anti-inflammatory drugs (NSAIDs) have a long clinical use for the treatment of various
inflammatory diseases like different forms of arthritis. NSAIDs inhibit prostaglandin synthesis by inhibition of
enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). COX-1 was described as “constutive”
controlling normal homeostasis, and COX-2 as “inflammatory”, involved in pathological pr…